When standard blood work comes back "normal" but you're exhausted, we test for these eight energy roadblocks:
1. Thyroid Dysfunction Beyond TSH
You can have normal TSH but terrible T3 conversion. Reverse T3 can block T3 from working. Thyroid antibodies can indicate autoimmune attacks.
Symptoms: Cold all the time, weight gain, brain fog, severe fatigue
2. Adrenal Dysfunction & Cortisol Dysregulation
Cortisol is supposed to give you energy in the morning and decrease at night. When this rhythm is off, you're wiped. High cortisol at night means you can't sleep. Low cortisol in the morning means you can't wake up.
Patterns: Feeling "wired and tired," crashing at specific times
3. Mitochondrial Dysfunction
Mitochondria are your cells' energy factories. When they're not working properly, you can't make energy no matter how much you sleep or eat.
Causes: Nutrient deficiencies, toxins, chronic stress, aging, inflammation
4. Iron Deficiency (Even With "Normal" Hemoglobin)
Your hemoglobin can be normal while your ferritin is critically low. Iron is essential for oxygen transport and energy production.
Classic pattern: Exhausted, always cold, pale skin, heavy periods
5. B Vitamin Deficiencies
B vitamins are essential for energy production. Low B12, folate, B6, B1, or B complex will cause severe fatigue.
Risk factors: Gut issues preventing absorption, vegetarian diet, MTHFR mutations
6. Chronic Inflammation
Your body is in constant state of immune activation, draining energy for "defense" instead of daily function.
Sources: Gut dysfunction, food sensitivities, autoimmunity, toxins, chronic stress
7. Hormone Imbalances
Estrogen dominance, low progesterone, or perimenopause can cause severe fatigue. Hormones affect energy production, sleep quality, and thyroid function. Often overlaps with thyroid dysfunction.
8. Gut Dysfunction Affecting Nutrient Absorption
SIBO, leaky gut, or dysbiosis prevents nutrient absorption. You can't make energy without nutrients.
Symptoms: Bloating, irregular bowels, food sensitivities plus fatigue
The pattern we see constantly: Women with 3-5 of these issues happening at once. Your fatigue isn't one thing. It's a perfect storm of thyroid plus cortisol plus nutrients plus inflammation. And standard blood work catches none of it.
When Rest Doesn't Help (And Why Doctors Are Stumped)
"Have you tried sleeping more?"
Yes. You've tried everything. You sleep 8-9 hours and wake up exhausted. Here's why:
It's Not About Sleep Duration. It's About Energy Production.
Sleep helps recovery, but can't fix broken mitochondria. You can't sleep your way out of nutrient deficiencies. You can't rest away thyroid dysfunction.
The problem isn't lack of sleep. It's inability to produce energy.
Cortisol Dysregulation Prevents Restorative Sleep
High cortisol at night means you can't fall asleep or stay asleep
Low cortisol in the morning means you can't wake up
Cortisol crashes throughout the day mean you're exhausted at 2 PM
More sleep doesn't fix cortisol patterns.
Inflammation Causes Non-Restorative Sleep
You're sleeping but not reaching deep sleep stages. You wake up feeling like you didn't sleep at all. Your body is stuck in light sleep due to inflammation.
The Fatigue Is Coming From Cellular Dysfunction
The problem isn't in your muscles. It's in your cells. Mitochondria can't make ATP. Energy production pathways are broken. More rest doesn't fix metabolic problems at the cellular level.
Why Your Doctor Says "Everything's Fine" (When You're Clearly Not)
Testing Is Designed to Rule Out Disease, Not Optimize Function
Standard labs are designed to catch:
Severe anemia
Kidney failure
Liver disease
Diabetes
They're not designed to catch:
Suboptimal thyroid
Low-grade inflammation
Nutrient deficiencies
Subtle hormone imbalances
"Normal" means "not dying," not "feeling good."
Fatigue Gets Blamed on Mental Health
Can't find a cause equals depression diagnosis. Antidepressants get prescribed. Underlying metabolic dysfunction never gets addressed.
Some cases ARE depression, but many are missed thyroid, hormone, or nutrient issues that get misdiagnosed.
No Time for Complex Cases
Ten to 15 minute appointments can't dig into multifactorial fatigue. It's easier to say "it's stress" than investigate thyroid conversion, cortisol rhythm, and nutrient status.
Complex cases need comprehensive testing, not quick dismissals.
Insurance Won't Pay for Comprehensive Testing
Insurance won't cover:
4-point cortisol
Organic acids
Comprehensive nutrient testing
Hormone metabolites
They only cover:
Basic CBC
CMP
Maybe TSH
Can't diagnose what you can't test. Insurance-driven care keeps testing limited.
The Result
Women get told "you're fine" or "it's in your head" when they have multiple, measurable, fixable metabolic dysfunctions. That's why we test comprehensively to find what's actually broken.
Trusted by 500+ clients
+41

Read Our Google Reviews
Prefer to chat first? Send us an email or connect with us on social — we’re always happy to help.




